Scaling up of dihydropyridine ester synthesis by using aqueous hydrotrope solutions in a continuous microwave reactor

被引：53

作者：

Khadilkar, BM ^{[1
]}

Madyar, VR ^{[1
]}

机构：

[1] Univ Mumbai, Dept Chem Technol, Matunga 400019, Mumbai, India

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 04期

关键词：

D O I：

10.1021/op010026q

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report here the scaling up of clinically important dihydropyridine by using a continuous microwave reactor (CMR). We also report the use of aqueous hydrotrope solution as a cheap, safe and "green" alternative to organic solvent to carry out homogeneous reactions under microwave heating. We have studied different aqueous hydrotrope solutions for the reaction in batch as well as continuous-flow process.

引用

页码：452 / 455

页数：4

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