1,4-DIHYDROPYRIDINE ANTAGONIST ACTIVITIES AT THE CALCIUM-CHANNEL - A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP APPROACH

被引：131

作者：

COBURN, RA ^{[1
]}

WIERZBA, M ^{[1
]}

SUTO, MJ ^{[1
]}

SOLO, AJ ^{[1
]}

TRIGGLE, AM ^{[1
]}

TRIGGLE, DJ ^{[1
]}

机构：

[1] SUNY BUFFALO, SCH PHARM, DEPT MED MICROBIOL, BUFFALO, NY 14260 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 11期

关键词：

D O I：

10.1021/jm00119a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2103 / 2107

页数：5

共 21 条

[1] DIETHYL 3,6-DIHYDRO-2,4-DIMETHYL-2,6-METHANO-1,3-BENZOTHIAZOCINE-5,11-DICARBOXYLATES AS CALCIUM ENTRY ANTAGONISTS - NEW CONFORMATIONALLY RESTRAINED ANALOGS OF HANTZSCH 1,4-DIHYDROPYRIDINES RELATED TO NITRENDIPINE AS PROBES FOR RECEPTOR-SITE CONFORMATIONE [J].

BALDWIN, JJ ;

CLAREMON, DA ;

LUMMA, PK ;

MCCLURE, DE ;

ROSENTHAL, SA ;

WINQUIST, RJ ;

FAISON, EP ;

KACZOROWSKI, GJ ;

TRUMBLE, MJ ;

SMITH, GM .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) :690-695

[2] COMPARISON BETWEEN X-RAY CRYSTALLOGRAPHIC DATA AND PHYSICOCHEMICAL PARAMETERS WITH RESPECT TO THEIR INFORMATION ABOUT THE CALCIUM-CHANNEL ANTAGONIST ACTIVITY OF 4-PHENYL-1,4-DIHYDROPYRIDINES [J].

BERNTSSON, P ;

WOLD, S .

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, 1986, 5 (02) :45-50

[3]

BOLGER GT, 1983, J PHARMACOL EXP THER, V225, P291

[4] DIFFERENTIAL SENSITIVITY OF CALCIUM CHANNELS TO DIHYDROPYRIDINES - THE MODULATED RECEPTOR HYPOTHESIS [J].

CHIN, JH .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (23) :4115-4120

[5]

COBURN RA, IN PRESS QSAR PC

[6] SUBSTITUTED STYRENES .6. SYNTHESES OF ISOMERIC FORMYLSTYRENES AND O- AND M-VINYLBENZOIC ACID [J].

DALE, WJ ;

STARR, L ;

STROBEL, CW .

JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (07) :2225-&

[7] CRYSTAL-STRUCTURES AND PHARMACOLOGIC ACTIVITIES OF 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL ANTAGONISTS OF THE ISOBUTYL METHYL 2,6-DIMETHYL-4-(SUBSTITUTED PHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE (NISOLDIPINE) SERIES [J].

FOSSHEIM, R ;

JOSLYN, A ;

SOLO, AJ ;

LUCHOWSKI, E ;

RUTLEDGE, A ;

TRIGGLE, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (02) :300-305

[8] CRYSTAL-STRUCTURES AND PHARMACOLOGICAL ACTIVITY OF CALCIUM-CHANNEL ANTAGONISTS - 2,6-DIMETHYL-3,5-DICARBOMETHOXY-4-(UNSUBSTITUTED, 3-METHYL-PHENYL, 4-METHYL-PHENYL, 3-NITRO-PHENYL, 4-NITRO-PHENYL, AND 2,4-DINITROPHENYL)-1,4-DIHYDROPYRIDINE [J].

FOSSHEIM, R ;

SVARTENG, K ;

MOSTAD, A ;

ROMMING, C ;

SHEFTER, E ;

TRIGGLE, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (02) :126-131

[9]

Hansch C, 1979, SUBSTITUENT CONSTANT

[10] STEREOSELECTIVITY AT THE CALCIUM-CHANNEL - OPPOSITE ACTION OF THE ENANTIOMERS OF A 1,4-DIHYDROPYRIDINE [J].

HOF, RP ;

RUEGG, UT ;

HOF, A ;

VOGEL, A .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1985, 7 (04) :689-693

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