Familial influences and obesity-associated metabolic risk factors contribute to the variation in resting energy expenditure:: the Kiel Obesity Prevention Study

被引：37

作者：

Bosy-Westphal, Anja ^{[1
]}

Wolf, Andreas ^{[2
]}

Buehrens, Frederike ^{[1
]}

Hitze, Britta ^{[1
]}

Czech, Norbert ^{[3
]}

Moenig, Heiner ^{[4
]}

Selberg, Oliver ^{[5
]}

Settler, Uta ^{[1
]}

Pfeuffer, Maria ^{[6
]}

Schrezenmeir, Juergen ^{[6
]}

Krawczak, Michael ^{[2
]}

Mueller, Manfred J. ^{[1
]}

机构：

[1] Univ Kiel, Inst Humanernahrung & Lebensmittelkunde, Agrar & Ernahrungswissensch Fak, D-24105 Kiel, Germany

[2] Univ Kiel, Inst Med Informat & Stat, D-24105 Kiel, Germany

[3] Univ Kiel, Abt Nukl Med, Radiol Diagnost Klin, D-24105 Kiel, Germany

[4] Univ Kiel, Klin Allgemeine Innere Med, D-24105 Kiel, Germany

[5] Stadt Klinikum Braunschweig, Klin Chem Abt, Braunschweig, Germany

[6] Bundesforschungsanstalt Ernahrung & Lebensmittel, Kiel, Germany

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2008年 / 87卷 / 06期

关键词：

D O I：

10.1093/ajcn/87.6.1695

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: A low metabolic rate may be inherited and predispose to obesity, whereas a higher metabolic rate in obesity may be acquired by obesity-associated cardiometabolic risk. Objective: We aimed to explain the interindividual variation in resting energy expenditure (REE) by assessing 1) the association between REE and body composition, thyroid hormones, and obesity-related cardiometabolic risk factors, and 2) the familial (genetic and environmental) contribution to REE. Design: REE and metabolic risk factors (ie, blood pressure and plasma insulin, glucose, and C-reactive protein concentrations) were assessed in 149 two- or three-generation families, including at least one overweight or obese member. Heritability of REE, respiratory quotient (RQ), thyroid hormones [thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4)], and body composition (fat-free mass and fat mass) were estimated by using variance components- based quantitative genetic models. Results: REE adjusted for body composition, sex, and age (REEadj) significantly correlated with systolic and diastolic blood pressure, plasma insulin and glucose concentrations, and the homeostasis model assessment (HOMA) (r = 0.14 - 0.31, P < 0.05). Thyroid hormones had a modest influence on REE variance only. Heritability was 0.30 +/- 0.07 for REEadj and 0.29 +/- 0.08 for REE after additional adjustment for thyroid hormones and metabolic risk. Furthermore, heritability was estimated to be 0.22 +/- 0.08 for RQ, 0.37 +/- 0.08 for TSH, 0.68 +/- 0.06 for FT4, and 0.69 +/- 0.05 for FT3 (all significantly larger than zero). Conclusions: Obesity-related cardiometabolic risk factors contribute to interindividual variation in REE, with hypertension and insulin resistance being associated with a higher REE. REE was moderately heritable, independent of body composition, sex, age, thyroid function, and cardiometabolic risk.

引用

页码：1695 / 1701

页数：7

共 47 条

[31] Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates [J].

Pannacciulli, N ;

Bunt, JC ;

Ortega, E ;

Funahashi, T ;

Salbe, AD ;

Bogardus, C ;

Krakoff, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (04) :1600-1603

[32] Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes:: Potential role of PGC1 and NRF1 [J].

Patti, ME ;

Butte, AJ ;

Crunkhorn, S ;

Cusi, K ;

Berria, R ;

Kashyap, S ;

Miyazaki, Y ;

Kohane, I ;

Costello, M ;

Saccone, R ;

Landaker, EJ ;

Goldfine, AB ;

Mun, E ;

DeFronzo, R ;

Finlayson, J ;

Kahn, CR ;

Mandarino, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8466-8471

[33] Resting energy expenditure in diabetic and nondiabetic patients with liver cirrhosis: relation with insulin sensitivity and effect of liver transplantation and immunosuppressive therapy [J].

Perseghin, G ;

Mazzaferro, V ;

Benedini, S ;

Pulvirenti, A ;

Coppa, J ;

Regalia, E ;

Luzi, L .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (03) :541-548

[34] Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes [J].

Petersen, KF ;

Dufour, S ;

Befroy, D ;

Garcia, R ;

Shulman, GI .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (07) :664-671

[35] Mitochondrial dysfunction in the elderly: Possible role in insulin resistance [J].

Petersen, KF ;

Befroy, D ;

Dufour, S ;

Dziura, J ;

Ariyan, C ;

Rothman, DL ;

DiPietro, L ;

Cline, GW ;

Shulman, GI .

SCIENCE, 2003, 300 (5622) :1140-1142

[36]

PRENTICE AM, 1986, BRIT MED J, V292, P983, DOI 10.1136/bmj.292.6526.983

[37]

RAIKINEN T, 2006, OBESITY, V14, P529

[38] Genetic pleiotropy for resting metabolic rate with fat-free mass and fat mass: The Quebec family study [J].

Rice, T ;

Tremblay, A ;

Deriaz, O ;

Perusse, L ;

Rao, DC ;

Bouchard, C .

OBESITY RESEARCH, 1996, 4 (02) :125-131

[39] Resting energy expenditure is not increased in mildly hyperglycaemic obese diabetic patients [J].

Ryan, M. ;

Salle, A. ;

Guilloteau, G. ;

Genaitay, M. ;

Livingstone, M. B. E. ;

Ritz, P. .

BRITISH JOURNAL OF NUTRITION, 2006, 96 (05) :945-948

[40]

Siri W.E., 1961, Techniques for measuring body composition, P223

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