Macrophage colony stimulating factor promotes phagocytosis by murine microglia

被引：40

作者：

Mitrasinovic, OM ^{[1
]}

Vincent, VAM ^{[1
]}

Simsek, D ^{[1
]}

Murphy, GM ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Neurosci Res Labs, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

来源：

NEUROSCIENCE LETTERS | 2003年 / 344卷 / 03期

关键词：

macrophage colony stimulating factor; microglial phagocytosis; Alzheimer's disease; amyloid beta;

D O I：

10.1016/S0304-3940(03)00474-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Macrophage colony stimulating factor (M-CSF) and its receptor are upregulated in the brain in Alzheimer's disease. M-CSF induces activation and proliferation of microglial cells and expression of proinflammatory cytokines. Amyloid beta (Abeta) immunization experiments suggest that microglia have the capacity to aggressively clear Abeta from the brain under certain circumstances. We examined the role of M-CSF in phagocytosis of fluorescent microspheres and Abeta by cultured microglia. M-CSF treatment increased microglial cell phagocytosis of both microspheres and of Abeta. Antibody neutralization of M-CSF inhibited Abeta uptake induced by overexpression of the M-CSF receptor on microglia. These results suggest that M-CSF could be important in promoting microglial clearance of abnormal protein aggregates such as Abeta. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：185 / 188

页数：4

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