The many roles of the transcriptional regulator CTCF

被引：57

作者：

Dunn, KL ^{[1
]}

Davie, JR ^{[1
]}

机构：

[1] Univ Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2003年 / 81卷 / 03期

关键词：

CTCF; insulator; transcription;

D O I：

10.1139/o03-052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear factor CTCF was first identified as one of the factors binding to the regulatory regions of the c-myc gene. Further study of this protein revealed roles in transcriptional repression, insulator function, and imprinting genetic information. Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation.

引用

页码：161 / 167

页数：7

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