Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells

被引：45

作者：

Siriwan, Dalad ^{[1
]}

Naruse, Takayuki ^{[2
]}

Tamura, Hirotoshi ^{[2
]}

机构：

[1] Ehime Univ, United Grad Sch Agr Sci, Matsuyama, Ehime 7908566, Japan

[2] Kagawa Univ, Fac Agr, Dept Appl Biol Sci, Miki, Kagawa 7610795, Japan

来源：

FITOTERAPIA | 2011年 / 82卷 / 07期

关键词：

Sesquiterpene lactones; Smallanthus sonchifolius; Apoptosis; NF-kappa B; Caspase-3/7; HeLa cells; BIOLOGICAL-ACTIVITIES; HELA-CELLS; IN-VITRO; INDUCTION; TRANSCRIPTION; P65/NF-KAPPA-B; PROLIFERATION; CYTOTOXICITY; MELAMPOLIDES; ACTIVATION;

D O I：

10.1016/j.fitote.2011.07.007

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The present study investigated the cytotoxicity of enhydrin (1), uvedalin (2) and sonchifolin (3) in cervical cancer cells. We have found that SLs 1-3 in doses in range of 0.22-10 mu M inhibited cell proliferation and induced apoptosis in both a dose- and time-dependent fashion. A significant cell death induction was supported by morphological studies. The apoptotic effect is associated with caspase-3/7 activation and NF-kappa B inhibition. Interestingly, enhydrin possessing two epoxide units was found to be the most cytotoxic compound. Therefore it can be assumed that number of epoxides and existence of alpha-methylene-gamma-lactone moiety are essential for the acceleration of apoptosis. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：1093 / 1101

页数：9

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