The synthesis of a chiral fluoxetine intermediate by catalytic enantioselective hydrogenation of benzoylacetamide

被引：27

作者：

Huang, HL ^{[1
]}

Liu, LT ^{[1
]}

Chen, SF ^{[1
]}

Ku, H ^{[1
]}

机构：

[1] Dev Ctr Biotechnol, Taipei, Taiwan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(98)00158-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the presence of a chiral BINAP-ruthenium(II) catalyst, asymmetric hydrogenation of beta-keto propanoic acid N-methyl amide under 200 psi of hydrogen pressure furnished the corresponding 3-hydroxypropanoic acid N-methyl amide as the single enantiomer. The product can be used as an intermediate for chiral fluoxetine. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：1637 / 1640

页数：4

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