Increased release of IAPP in response to long-term high fat intake in mice

被引：16

作者：

Westermark, GT ^{[1
]}

Leckström, A ^{[1
]}

Ma, Z ^{[1
]}

Westermark, P ^{[1
]}

机构：

[1] Linkoping Univ, Fac Hlth Sci, Div Mol & Immunol Pathol, Linkoping, Sweden

来源：

HORMONE AND METABOLIC RESEARCH | 1998年 / 30卷 / 05期

关键词：

islet amyloid polypeptide (IAPP); insulin; free fatty acid (FFA);

D O I：

10.1055/s-2007-978878

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the present study, mice were fed high-fat diet or standard animal chow during 6 months. Animals fed high-fat diet showed a 4.5-fold increase in the fasting plasma IAPP levels compared to animals fed standard chow. No significant change in plasma insulin levels occurred between the groups. These differences in hormone response result in a change of the molar ratio between IAPP and insulin in the group fed high-fat diet. An increased IAPP to insulin molar ratio might be important in the pathogenesis of islet amyloid in man.

引用

页码：256 / 258

页数：3

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