Chiral amidomonophosphine-rhodium(I) catalyst for asymmetric 1,4-addition of arylboronic acids to cycloalkenones

被引：90

作者：

Kuriyama, M ^{[1
]}

Tomioka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 05期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(00)02130-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric 1,4-addition reaction of arylboronic acids with cycloalkenones was catalyzed by 1 mol% of an amidomonophosphine-rhodium(I) catalyst in a 10:1 mixture of dioxane and water at 100 degreesC, affording 3-arylcycloalkanones in reasonably high enantioselectivity (up to 960% ee) and high yields (up to 99%). The reaction efficacy of phenylboronic acid with cyclohex-2-enone was significantly dependent on the initiation procedure when BINAP was used as a phosphine. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：921 / 923

页数：3

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