Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population

被引：46

作者：

Inoue, R. ^{[1
]}

Ishibashi, Y. ^{[1
]}

Tsuda, E. ^{[1
]}

Yamamoto, Y. ^{[1
]}

Matsuzaka, M. ^{[2
]}

Takahashi, I. ^{[2
]}

Danjo, K. ^{[2
]}

Umeda, T. ^{[2
]}

Nakaji, S. ^{[2
]}

Toh, S. ^{[1
]}

机构：

[1] Hirosaki Univ, Grad Sch Med, Dept Orthopaed Surg, Aomori 0368562, Japan

[2] Hirosaki Univ, Grad Sch Med, Dept Social Med, Aomori 0368562, Japan

来源：

OSTEOARTHRITIS AND CARTILAGE | 2011年 / 19卷 / 01期

关键词：

Serum hyaluronan; Knee osteoarthritis; Knee pain; Biomarker; Japanese; Health checkups; OUTCOME SCORE KOOS; CIRCULATING HYALURONATE; RHEUMATOID-ARTHRITIS; BIOCHEMICAL MARKERS; DISEASE PROGRESSION; HIP OSTEOARTHRITIS; PLASMA HYALURONAN; ACID; CARTILAGE; PREVALENCE;

D O I：

10.1016/j.joca.2010.10.021

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Objective: To investigate relationship between serum hyaluronan (HA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain in Japanese population. Design: A total of 616 volunteers participated in this study. Based on the Kellgren-Lawrence (K-L) grade, participants were radiographically classified into three groups: Normal (K-L grade 0 or 1), Moderate (grade 2) and Severe (grade 3 or 4). The degree of knee pain was quantified by visual analogue scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS) Pain. Serum HA levels were compared among the Normal, Moderate and Severe groups, and the relationship between serum HA level and the severity of knee OA was analyzed after age, sex and body mass index (BMI) were adjusted. In addition, the correlation between serum HA level and the degree of knee pain was analyzed in each group. Results: Regarding relationship between serum HA level and the severity of radiographic knee OA, serum HA levels of the Moderate and Severe groups were significantly higher than in the Normal group (P < 0.001). Furthermore, serum HA level correlated with the severity of radiographic knee OA (r = 0.289, P < 0.001) after adjusting for age, sex and BMI. Serum HA level correlated with VAS of knee pain and/or KOOS Pain in the Normal and Moderate groups. Conclusion: Serum HA level has the potential to be useful for the diagnosis of the presence and severity of knee OA. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：51 / 57

页数：7

共 49 条

[1]

Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study [J].

Bruyere, O. ;

Collette, J. ;

Kothari, M. ;

Zaim, S. ;

White, D. ;

Genant, H. ;

Peterfy, C. ;

Burlet, N. ;

Ethgen, D. ;

Montague, T. ;

Dabrowski, C. ;

Reginster, J-Y .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (08) :1050-1054

[2]

Bruyere O, 2003, J RHEUMATOL, V30, P1043

[3]

Translating health status questionnaires and evaluating their quality:: The IQOLA project approach [J].

Bullinger, M ;

Alonso, J ;

Apolone, G ;

Leplège, A ;

Sullivan, M ;

Wood-Dauphinee, S ;

Gandek, B ;

Wagner, A ;

Aaronson, N ;

Bech, P ;

Fukuhara, S ;

Kaasa, S ;

Ware, JE .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1998, 51 (11) :913-923

[4]

The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis [J].

Cahue, S. ;

Sharma, L. ;

Dunlop, D. ;

Ionescu, M. ;

Song, J. ;

Lobanok, T. ;

King, L. ;

Poole, A. Robin .

OSTEOARTHRITIS AND CARTILAGE, 2007, 15 (07) :819-823

[5]

Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee [J].

Chua, S. D. ;

Messier, S. P. ;

Legault, C. ;

Lenz, M. E. ;

Thonar, E. J. -M. A. ;

Loeser, R. F. .

OSTEOARTHRITIS AND CARTILAGE, 2008, 16 (09) :1047-1053

[6]

Association of Biomarkers With Pre-Radiographically Defined and Radiographically Defined Knee Osteoarthritis in a Population-Based Study [J].

Cibere, Jolanda ;

Zhang, Hongbin ;

Garnero, Patrick ;

Poole, A. Robin ;

Lobanok, Tatiana ;

Saxne, Tore ;

Kraus, Virginia B. ;

Way, Amanda ;

Thorne, Anona ;

Wong, Hubert ;

Singer, Joel ;

Kopec, Jacek ;

Guermazi, Ali ;

Peterfy, Charles ;

Nicolaou, Savvakis ;

Munk, Peter L. ;

Esdaile, John M. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (05) :1372-1380

[7]

Variation of serum hyaluronan with activity in individuals with knee osteoarthritis [J].

Criscione, LG ;

Elliott, AL ;

Stabler, T ;

Jordan, JM ;

Pieper, CF ;

Kraus, VB .

OSTEOARTHRITIS AND CARTILAGE, 2005, 13 (09) :837-840

[8]

EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Prevalence of inflammation in osteoarthritis [J].

D'Agostino, MA ;

Conaghan, P ;

Le Bars, M ;

Baron, G ;

Grassi, W ;

Martin-Mola, E ;

Wakefield, R ;

Brasseur, JL ;

So, A ;

Backhaus, M ;

Malaise, M ;

Burmester, G ;

Schmidely, N ;

Ravaud, P ;

Dougados, M ;

Emery, P .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (12) :1703-1709

[9]

The natural history of cartilage defects in people with knee osteloarthritis [J].

Davies-Tuck, M. L. ;

Wluka, Anita ;

Wang, Y. ;

Teichtahl, A. J. ;

Ding, C. ;

Cicuttini, Flavia M. .

OSTEOARTHRITIS AND CARTILAGE, 2008, 16 (03) :337-342

[10]

Randomized clinical trial of therapeutic exercise in subacute stroke [J].

Duncan, P ;

Studenski, S ;

Richards, L ;

Gollub, S ;

Lai, SM ;

Reker, D ;

Perera, S ;

Yates, J ;

Koch, V ;

Rigler, S ;

Johnson, D .

STROKE, 2003, 34 (09) :2173-2180

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