Recognition of the DNA minor groove by pyrrole-imidazole polyamides

被引：558

作者：

Dervan, PB ^{[1
]}

Edelson, BS

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[2] CALTECH, Beckman Inst, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-440X(03)00081-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.

引用

页码：284 / 299

页数：16

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