The RCSB Protein Data Bank: views of structural biology for basic and applied research and education

被引：387

作者：

Rose, Peter W. ^{[1
]}

Prlic, Andreas ^{[1
]}

Bi, Chunxiao ^{[1
]}

Bluhm, Wolfgang F. ^{[1
]}

Christie, Cole H. ^{[1
]}

Dutta, Shuchismita ^{[2
]}

Green, Rachel Kramer ^{[2
]}

Goodsell, David S. ^{[4
]}

Westbrook, John D. ^{[2
]}

Woo, Jesse ^{[1
]}

Young, Jasmine ^{[2
]}

Zardecki, Christine ^{[2
]}

Berman, Helen M. ^{[2
]}

Bourne, Philip E. ^{[1
,5
]}

Burley, Stephen K. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Calif San Diego, San Diego Supercomp Ctr, RCSB Prot Data Bank, La Jolla, CA 92093 USA

[2] Rutgers State Univ, Dept Chem & Chem Biol, RCSB Prot Data Bank, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Ctr Integrat Prote Res, Piscataway, NJ 08854 USA

[4] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[5] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家科学基金会;

关键词：

VALIDATION; COMPLEXES; CELECOXIB; FRAMEWORK; SYSTEM; SITE; GPCR; NMR;

D O I：

10.1093/nar/gku1214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide. Our efforts over the past 2 years focused on enabling a deeper understanding of structural biology and providing new structural views of biology that support both basic and applied research and education. Herein, we describe recently introduced data annotations including integration with external biological resources, such as gene and drug databases, new visualization tools and improved support for the mobile web. We also describe access to data files, web services and open access software components to enable software developers to more effectively mine the PDB archive and related annotations. Our efforts are aimed at expanding the role of 3D structure in understanding biology and medicine.

引用

页码：D345 / D356

页数：12

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