The DNA repair gene ERCC2/XPD polyrnorphism Arg 156Arg (A22541C) and risk of lung cancer in a Chinese population

被引：32

作者：

Yin, JY

Li, JC ^{[1
]}

Ma, YG

Guo, L

Wang, HW

Vogel, U

机构：

[1] Zhejiang Univ, Inst Cell Biol, Hangzhou 310031, Zhejiang Prov, Peoples R China

[2] Shenyang Med Coll, Dept Med Genet, Shenyang 110034, Liaoning Prov, Peoples R China

[3] Natl Inst Occupat Hlth, DK-2100 Copenhagen, Denmark

[4] Liaoning Tumor Hosp, Dept Thorac Surg, Shenyang 110042, Liaoning Prov, Peoples R China

来源：

CANCER LETTERS | 2005年 / 223卷 / 02期

关键词：

ERCC2/XPD Argl56Arg (A22541C); genetic polymorphism; lung cancer; Chinese population;

D O I：

10.1016/j.canlet.2004.10.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To determine the effect of the DNA repair gene XPD Arg156Arg polymorphism on the risk of lung cancer in a North-Eastern Chinese population, a hospital-based case-control study was designed consisting of 149 newly diagnosis subjects with lung cancer and 137 cancer-free control subjects matched on age (+/- 3 years), gender and ethnicity. In the whole study group, XPD Arg156Arg was not associated with risk of lung cancer. In stratified analyses, the variant A-allele of XPD Arg156Arg was associated with increased risk of adenocarcinoma of lung (AA/AC versus CC; adjusted OR=1.65; 95% CI=1.09-2.50) (P=0.02). Furthermore, the presence of one or two variant A-alleles was associated with increased risk for lung cancer (OR=2.49; 95% CI=1.10-5.64) (P=0.03) and adenocarcinoma of lung (OR=5.60; 95% CI=1.52-20.56) (P=0.005) among never-smokers only. These results suggest a possible gene-environment interaction. This is the first study to report a significant association of XPD Arg156Arg with risk of lung cancer. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 226

页数：8

共 43 条

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