Chitosan: A unique polysaccharide for drug delivery

被引：580

作者：

Felt, O ^{[1
]}

Buri, P ^{[1
]}

Gurny, R ^{[1
]}

机构：

[1] Univ Geneva, Sch Pharm, CH-1211 Geneva 4, Switzerland

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1998年 / 24卷 / 11期

关键词：

chitosan; drug delivery; review;

D O I：

10.3109/03639049809089942

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this review is to give an insight into the many potential applications of chitosan as a pharmaceutical drug carrier The first part of this review concerns the principal uses of chitosan as an excipient in oral formulations (particularly as a direct tableting agent) and as a vehicle for pal-enteral dr-rig delivery devices. The use of chitosan to manufacture sustained-release systems deliverable by other routes (nasal, ophthalmic, transdermal, and implantable devices) is discussed in the second part.

引用

收藏

页码：979 / 993

页数：15

相关论文

共 125 条

[1]

ACIKGOZ M, 1995, PHARMAZIE, V50, P275

[2] Chitosan microspheres of diclofenac sodium .1. Application of factorial design and evaluation of release kinetics [J].

Acikgoz, M ;

Kas, HS ;

Orman, M ;

Hincal, AA .

JOURNAL OF MICROENCAPSULATION, 1996, 13 (02) :141-159

[3] PREPARATION AND EVALUATION OF CROSS-LINKED CHITOSAN MICROSPHERES CONTAINING FUROSEMIDE [J].

AKBUGA, J ;

DURMAZ, G .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1994, 111 (03) :217-222

[4] 5-fluorouracil-loaded chitosan microspheres: Preparation and release characteristics [J].

Akbuga, J ;

Bergisadi, N .

JOURNAL OF MICROENCAPSULATION, 1996, 13 (02) :161-168

[5]

[Anonymous], DRUG DELIVERY, DOI DOI 10.1155/2011/458128

[6] CHITOSAN AS A NASAL DELIVERY SYSTEM - EVALUATION OF THE EFFECT OF CHITOSAN ON MUCOCILIARY CLEARANCE RATE IN THE FROG PALATE MODEL [J].

ASPDEN, TJ ;

ADLER, J ;

DAVIS, SS ;

SKAUGRUD, O ;

ILLUM, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 122 (1-2) :69-78

[7] Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers [J].

Aspden, TJ ;

Mason, JDT ;

Jones, NS ;

Lowe, J ;

Skaugrud, O ;

Illum, L .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (04) :509-513

[8]

Balassa L. L., 1972, U. S. Patent, Patent No. [US3632754 (A), 3632754]

[9] IMPROVED METHOD FOR IR DETERMINATION OF THE DEGREE OF N-ACETYLATION OF CHITOSAN [J].

BAXTER, A ;

DILLON, M ;

TAYLOR, KDA ;

ROBERTS, GAF .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1992, 14 (03) :166-169

[10] Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for antiinflammatory drugs [J].

Berthold, A ;

Cremer, K ;

Kreuter, J .

JOURNAL OF CONTROLLED RELEASE, 1996, 39 (01) :17-25

← 1 2 3 4 5 6 7 8 9 10 →