Advances and challenges in targeting FGFR signalling in cancer

被引：720

作者：

Babina, Irina S. ^{[1
]}

Turner, Nicholas C. ^{[1
,2
]}

机构：

[1] Inst Canc Res, Breast Canc Now Res Ctr, London SW3 6JB, England

[2] Royal Marsden Hosp, Breast Unit, Fulham Rd, London SW3 6JJ, England

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 05期

关键词：

FIBROBLAST-GROWTH-FACTOR; FACTOR RECEPTOR 2; TYROSINE KINASE INHIBITOR; I DOSE-ESCALATION; GENE COPY NUMBER; PHASE-I; BREAST-CANCER; THERAPEUTIC TARGET; LUNG-CANCER; SELECTIVE INHIBITOR;

D O I：

10.1038/nrc.2017.8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed results with FGFR-targeted cancer therapies, revealing substantial complexity to targeting aberrant FGFR signalling. In this Review, we discuss the increasing understanding of the differences between diverse mechanisms of oncogenic activation of FGFR, and the factors that determine response and resistance to FGFR targeting.

引用

页码：318 / 332

页数：15

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