Copper-Mediated Amidation of Heterocyclic and Aromatic C-H Bonds

被引：285

作者：

Wang, Qiu

Schreiber, Stuart L. ^{[1
]}

机构：

[1] Broad Inst, Howard Hughes Med Inst, Cambridge, MA 02142 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 22期

关键词：

CATALYZED SYNTHESIS; CUPRIC ACETATE; AMINATION; DISCOVERY; CHROMATIN; INHIBITORS; ARYLATION; ACIDS; DRUG; BETA;

D O I：

10.1021/ol902079g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as Inhibitors of HMTs.

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收藏

页码：5178 / 5180

页数：3

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