The role of porphyrin chemistry in tumor imaging and photodynamic therapy

被引：2116

作者：

Ethirajan, Manivannan ^{[1
]}

Chen, Yihui ^{[1
]}

Joshi, Penny ^{[1
]}

Pandey, Ravindra K. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, PDT Ctr, Buffalo, NY 14263 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 01期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; TOPICAL 5-AMINOLEVULINIC ACID; VIVO PHOTOSENSITIZING EFFICACY; PHASE-I TRIAL; PYROPHEOPHORBIDE-A; CANINE PROSTATE; PHOTOPHYSICAL PROPERTIES; ETIOPURPURIN DICHLORIDE; CLINICAL-EXPERIENCE; FLUORESCENT-PROBES;

D O I：

10.1039/b915149b

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

In recent years several review articles and books have been published on the use of porphyrin-based compounds in photodynamic therapy (PDT). This critical review is focused on (i) the basic concept of PDT, (ii) advantages of long-wavelength absorbing photosensitizers (PS), (iii) a brief discussion on recent advances in developing PDT agents, and (iv) the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo, for developing highly effective long-wavelength PDT agents and their utility in constructing the conjugates with tumor-imaging and therapeutic potential (Theranostics). The clinical status of certain selected PDT agents is also summarized (205 references).

引用

页码：340 / 362

页数：23

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