Optimisation of Conoidin A, a Peroxiredoxin Inhibitor

被引：26

作者：

Liu, Gu ^{[1
]}

Botting, Catherine H. ^{[1
]}

Evans, Kathryn M. ^{[1
]}

Walton, Jeffrey A. G. ^{[1
]}

Xu, Guogang ^{[1
]}

Slawin, Alexandra M. Z. ^{[1
]}

Westwood, Nicholas J. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem & Biomed Sci Res Complex, St Andrews KY16 9ST, Fife, Scotland

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 01期

基金：

英国惠康基金;

关键词：

conoidin A; inhibitors; molecular modeling; peroxiredoxin; Toxoplasma gondii; TOXOPLASMA-GONDII; HYDROGEN-PEROXIDE; ANTIOXIDANT; DEFENSE; MECHANISMS; TARGETS;

D O I：

10.1002/cmdc.200900391

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lead optimisation: Interest in the inhibition of peroxiredoxin has been revitalised by their recently identified role in signalling cascades. Here, the synthesis and analysis of novel analogues of the peroxiredoxin inhibitor conoidin A is described. Computational methods are used to rationalise the generated SAR data. These studies lead to a proposed binding mode for this class of compounds that will aid the design of second generation inhibitors. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：41 / 45

页数：5

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