Elaboration of the preliminary Rheumatoid Arthritis Impact of Disease (RAID) score: a EULAR initiative

被引：181

作者：

Gossec, L. ^{[1
,2
]}

Dougados, M. ^{[1
]}

Rincheval, N. ^{[2
]}

Balanescu, A. ^{[3
]}

Boumpas, D. T. ^{[4
]}

Canadelo, S. ^{[5
]}

Carmona, L. ^{[6
]}

Daures, J-P ^{[2
]}

de Wit, M. ^{[5
]}

Dijkmans, B. A. C. ^{[7
]}

Englbrecht, M. ^{[8
]}

Gunendi, Z. ^{[9
]}

Heiberg, T. ^{[10
]}

Kirwan, J. R. ^{[11
]}

Mola, E. M. ^{[12
]}

Matucci-Cerinic, M. ^{[13
]}

Otsa, K.

Schett, G. ^{[8
]}

Sokka, T. ^{[15
]}

Wells, G. A. ^{[16
]}

Aanerud, G. J. ^{[10
]}

Celano, A. ^{[13
]}

Dudkin, A. ^{[14
]}

Hernandez, C. ^{[12
]}

Koutsogianni, K. ^{[4
]}

Akca, F. N. ^{[9
]}

Petre, A-M ^{[3
]}

Richards, P. ^{[11
]}

Scholte-Voshaar, M. ^{[7
]}

Von Krause, G. ^{[1
]}

Kvien, T. K. ^{[17
,18
]}

机构：

[1] Paris Descartes Univ, Cochin Hosp, AP HP, Med Fac,UPRES EA 4058,Rheumatol Dept B, Paris, France

[2] Fac Med Montpellier, Epidemiol & Stat Dept, Montpellier, France

[3] Univ Med & Pharm Carol Davila, Sf Maria Hosp, Res Ctr Rheumat Dis, Bucharest, Romania

[4] Univ Crete, Fac Med, Iraklion, Greece

[5] EULAR Standing Comm People Arthrit Rheumatism Eur, Zurich, Switzerland

[6] Spanish Fdn Rheumatol, Res Unit, Madrid, Spain

[7] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

[8] Univ Erlangen Nurnberg, Dept Internal Med 3, Erlangen, Germany

[9] Gazi Univ, Dept Phys Med & Rehabil, Div Rheumatol, Ankara, Turkey

[10] Ullevaal Univ Hosp, Dept Res & Educ, Oslo, Norway

[11] Univ Bristol, Bristol Royal Infirm, Acad Rheumatol Unit, Bristol, Avon, England

[12] Hosp Univ La Paz, Dept Rheumatol, Madrid, Spain

[13] Univ Florence, Dept Med, Div Rheumatol AOUC, Denothe Ctr, Florence, Italy

[14] Tallinn Cent Hosp, Dept Rheumatol, Tallinn, Estonia

[15] Jyvaskyla Cent Hosp, Jyvaskyla, Finland

[16] Univ Ottawa, Inst Heart, Ottawa, ON, Canada

[17] Diakonhjemmet Hosp, Dept Rheumatol, Oslo, Norway

[18] Univ Oslo, Fac Med, Oslo, Norway

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2009年 / 68卷 / 11期

关键词：

PATIENT PERSPECTIVE; CORE SET; INTERNATIONAL CLASSIFICATION; OUTCOME MEASURES; WORK DISABILITY; CLINICAL-TRIALS; SOCIAL SUPPORT; ACTIVITY INDEX; HEALTH-STATUS; MORTALITY;

D O I：

10.1136/ard.2008.100271

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Current response criteria in rheumatoid arthritis ( RA) usually assess only three patient-reported outcomes PROs): pain, functional disability and patient global assessment. Other important PROs such as fatigue are not included. Objective: To elaborate a patient-derived composite response index for use in clinical trials in RA, the RA Impact of Disease ( RAID) score. Methods: Ten patients identified 17 domains or areas of health relevant for inclusion in the score, then 96 patients ( 10 per country in 10 European countries) ranked these domains in order of decreasing importance. The seven most important domains were selected. Instruments were chosen for each domain after extensive literature research of psychometric properties and expert opinion. The relative weight of each of the domains was obtained from 505 patients who were asked to "distribute 100 points'' among the seven domains. The average ranks of importance of these domains were then computed. Results: The RAID score includes seven domains with the following relative weights: pain (21%), functional disability (16%), fatigue (15%), emotional well-being (12%), sleep ( 12%), coping ( 12%) and physical well-being (12%). Weights were similar across countries and across patient and disease characteristics. Proposed instruments include the Health Assessment Questionnaire and numerical ratings scales. Conclusion: The preliminary RAID score is a patient-derived weighted score to assess the impact of RA. An ongoing study will allow the final choice of questionnaires and assessment of validity. This score can be used in clinical trials as a new composite index that captures information relevant to patients.

引用

页码：1680 / 1685

页数：6

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