Glucose biosensors based on organic light-emitting devices structurally integrated with a luminescent sensing element

被引:82
作者
Choudhury, B
Shinar, R [1 ]
Shinar, J
机构
[1] Iowa State Univ, Microelect Res Ctr, Ames, IA 50011 USA
[2] Iowa State Univ, Dept Elect & Comp Engn, Ames, IA 50011 USA
[3] Iowa State Univ, Ames Lab, US DOE, Ames, IA 50011 USA
[4] Iowa State Univ, Dept Phys & Astron, Ames, IA 50011 USA
基金
美国国家航空航天局; 美国能源部;
关键词
D O I
10.1063/1.1778477
中图分类号
O59 [应用物理学];
学科分类号
摘要
A platform for photoluminescence (PL) based biosensing is demonstrated for glucose. The sensor is structurally integrated, i.e., individually addressable organic light-emitting device (OLED) pixels (serving as the light source) and the sensing element are fabricated on glass or plastic substrates attached back-to-back. This results in a very compact, potentially miniaturizable sensor, which should strongly impact PL-based biosensor technology. The sensing element is an oxygen-sensitive dye coembedded with glucose oxidase in a thin film or dissolved in solution. The glucose biosensor is demonstrated for two OLED/dye pairs: [blue OLED]/[Ru dye] and [green OLED]/[Pt dye]. Both PL-intensity and PL-lifetime modes are demonstrated for each pair; the lifetime mode eliminates the need for frequent sensor calibration. The sensor performance is evaluated in terms of design, dynamic range, limit of detection, and stability. The use of the glucose biosensor in conjunction with an oxygen sensor is also discussed. (C) 2004 American Institute of Physics.
引用
收藏
页码:2949 / 2954
页数:6
相关论文
共 33 条
[1]   Nearly 100% internal phosphorescence efficiency in an organic light-emitting device [J].
Adachi, C ;
Baldo, MA ;
Thompson, ME ;
Forrest, SR .
JOURNAL OF APPLIED PHYSICS, 2001, 90 (10) :5048-5051
[2]   Endothermic energy transfer: A mechanism for generating very efficient high-energy phosphorescent emission in organic materials [J].
Adachi, C ;
Kwong, RC ;
Djurovich, P ;
Adamovich, V ;
Baldo, MA ;
Thompson, ME ;
Forrest, SR .
APPLIED PHYSICS LETTERS, 2001, 79 (13) :2082-2084
[3]  
AYLOTT JW, 2001, Patent No. 6331438
[4]   PHOTOPHYSICS AND PHOTOCHEMISTRY OF OXYGEN SENSORS BASED ON LUMINESCENT TRANSITION-METAL COMPLEXES [J].
CARRAWAY, ER ;
DEMAS, JN ;
DEGRAFF, BA ;
BACON, JR .
ANALYTICAL CHEMISTRY, 1991, 63 (04) :337-342
[5]   Electroluminescence spikes, turn-off dynamics, and charge traps in organic light-emitting devices [J].
Cheon, KO ;
Shinar, J .
PHYSICAL REVIEW B, 2004, 69 (20) :201306-1
[6]   Bright white small molecular organic light-emitting devices based on a red-emitting guest-host layer and blue-emitting 4,4′-bis(2,2′-diphenylvinyl)-1,1′-biphenyl [J].
Cheon, KO ;
Shinar, J .
APPLIED PHYSICS LETTERS, 2002, 81 (09) :1738-1740
[7]   Optical sensor array and integrated light source [J].
Cho, EJ ;
Bright, FV .
ANALYTICAL CHEMISTRY, 2001, 73 (14) :3289-3293
[8]   Luminescent chemical and biological sensors based on the structural integration of an OLED excitation source with a sensing component [J].
Choudhury, B ;
Shinar, R ;
Shinar, J .
ORGANIC LIGHT-EMITTING MATERIALS AND DEVICES VII, 2004, 5214 :64-72
[9]   An optical glucose biosensor based on derived glucose oxidase immobilised onto a sol-gel matrix [J].
de Marcos, S ;
Galindo, J ;
Sierra, JF ;
Galbán, J ;
Castillo, JR .
SENSORS AND ACTUATORS B-CHEMICAL, 1999, 57 (1-3) :227-232
[10]   Optical solid-state oxygen sensors using metalloporphyrin complexes immobilized in suitable polymeric matrices [J].
DiMarco, G ;
Lanza, M .
SENSORS AND ACTUATORS B-CHEMICAL, 2000, 63 (1-2) :42-48