Treg and lupus

被引：53

作者：

Bonelli, M. ^{[1
]}

Smolen, J. S. ^{[1
]}

Scheinecker, C. ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Med 3, Div Rheumatol, Vienna, Austria

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2010年 / 69卷

关键词：

REGULATORY T-CELLS; SLE PATIENTS; ERYTHEMATOSUS SLE; PERIPHERAL-BLOOD; FOXP3; EXPRESSION; CD4(+)CD25(HIGH); NUMBER; POPULATION; INDUCTION; TOLERANCE;

D O I：

10.1136/ard.2009.117135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune diseases such as systemic lupus erythe-mathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and breakdown of peripheral tolerance mechanisms. In addition novel subsets of Treg might arise under specific autoimmune conditions as an effort to counteract autoimmunity. Advances in our understanding of how to characterise and manipulate Treg in patients with autoimmune diseases are required in order to develop new therapeutic strategies.

引用

页码：65 / 66

页数：2

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