Fluorescence superquenching of conjugated polyelectrolytes: applications for biosensing and drug discovery

被引：221

作者：

Achyuthan, KE ^{[1
]}

Bergstedt, TS ^{[1
]}

Chen, L ^{[1
]}

Jones, RM ^{[1
]}

Kumaraswamy, S ^{[1
]}

Kushon, SA ^{[1
]}

Ley, KD ^{[1
]}

Lu, L ^{[1
]}

McBranch, D ^{[1
]}

Mukundan, H ^{[1
]}

Rininsland, F ^{[1
]}

Shi, X ^{[1
]}

Xia, W ^{[1
]}

Whitten, DG ^{[1
]}

机构：

[1] QTL Biosyst LLC, Santa Fe, NM 87507 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2005年 / 15卷 / 27-28期

关键词：

D O I：

10.1039/b501314c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This "Applications" article focuses on superquenching of the fluorescence of conjugated polyelectrolytes and related fluorescent polyelectrolytes and its applications to biosensing. Superquenching can occur for both aqueous solutions of these polymers as well as for various supported formats. For biosensing the supported formats are generally most practical. Three practical sensing applications are reviewed: nucleic acids, protease enzyme activity assays and kinase/phosphatase assays based on metal-ion-mediated superquenching.

引用

页码：2648 / 2656

页数：9

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