Targeting protein-protein interactions, a wide open field for drug design

被引：76

作者：

Bakail, May ^{[1
,2
]}

Ochsenbein, Francoise ^{[1
,2
]}

机构：

[1] CEA, iBiTec S, SB2SM, Lab Biol Struct & Radiobiol, Batiment 144, F-91191 Gif Sur Yvette, France

[2] Univ Paris Saclay, Univ Paris 11, CEA, Inst Integrat Biol Cell I2BC,IBITECS,CNRS, F-91198 Gif Sur Yvette, France

来源：

COMPTES RENDUS CHIMIE | 2016年 / 19卷 / 1-2期

关键词：

Drug design; Protein-protein interaction; Structure; Small molecule; Antibody; Peptide; Peptidomimetic; P53; TUMOR-SUPPRESSOR; ALPHA-HELIX MIMICRY; CELL-PENETRATING PEPTIDES; SMALL-MOLECULE INHIBITORS; CRYSTAL-STRUCTURE; RATIONAL DESIGN; HOT-SPOT; COMPUTATIONAL DESIGN; THERAPEUTIC STRATEGY; OLIGOAMIDE-FOLDAMER;

D O I：

10.1016/j.crci.2015.12.004

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Targeting protein-protein interactions has long been considered as a very difficult if impossible task, but over the past decade, front lines have moved. The number of successful examples is exponentially growing. This review presents a rapid overview of recent advances in this field considering the strengths and weaknesses of the small molecule approaches and alternative strategies such as the selection or design of artificial antibodies, peptides or peptidomimetics. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS.

引用

页码：19 / 27

页数：9

共 151 条

[1]

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality [J].

Arkin, Michelle R. ;

Tang, Yinyan ;

Wells, James A. .

CHEMISTRY & BIOLOGY, 2014, 21 (09) :1102-1114

[2]

Binding of small molecules to an adaptive protein-protein interface [J].

Arkin, MR ;

Randal, M ;

DeLano, WL ;

Hyde, J ;

Luong, TN ;

Oslob, JD ;

Raphael, DR ;

Taylor, L ;

Wang, J ;

McDowell, RS ;

Wells, JA ;

Braisted, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1603-1608

[3]

2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature [J].

Azzarito, Valeria ;

Prabhakaran, Panchami ;

Bartlett, Alice I. ;

Murphy, Natasha S. ;

Hardie, Michaele J. ;

Kilner, Colin A. ;

Edwards, Thomas A. ;

Warriner, Stuart L. ;

Wilson, Andrew J. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (32) :6469-6472

[4]

The BRET technology and its application to screening assays [J].

Bacart, Johan ;

Corbel, Caroline ;

Jockers, Ralf ;

Bach, Stéphane ;

Couturier, Cyril .

Biotechnology Journal, 2008, 3 (03) :311-324

[5]

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions [J].

Basse, Marie Jeanne ;

Betzi, Stephane ;

Bourgeas, Raphael ;

Bouzidi, Sofia ;

Chetrit, Bernard ;

Hamon, Veronique ;

Morelli, Xavier ;

Roche, Philippe .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D824-D827

[6]

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes [J].

Baud, Matthias G. J. ;

Lin-Shiao, Enrique ;

Cardote, Teresa ;

Tallant, Cynthia ;

Pschibul, Annica ;

Chan, Kwok-Ho ;

Zengerle, Michael ;

Garcia, Jordi R. ;

Kwan, Terence T. -L. ;

Ferguson, Fleur M. ;

Ciulli, Alessio .

SCIENCE, 2014, 346 (6209) :638-641

[7]

Cell-penetrating peptides: 20 years later, where do we stand? [J].

Bechara, Cherine ;

Sagan, Sandrine .

FEBS LETTERS, 2013, 587 (12) :1693-1702

[8]

Protein-protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein [J].

Betzi, Stephane ;

Restouin, Audrey ;

Opi, Sandrine ;

Arold, Stefan T. ;

Parrot, Isabelle ;

Guerlesquin, Fransoise ;

Morelli, Xavier ;

Collette, Yves .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19256-19261

[9]

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies [J].

Bird, Gregory H. ;

Irimia, Adriana ;

Ofek, Gilad ;

Kwong, Peter D. ;

Wilson, Ian A. ;

Walensky, Loren D. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (12) :1058-1067

[10]

High-throughput crystallography for lead discovery in drug design [J].

Blundell, TL ;

Jhoti, H ;

Abell, C .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (01) :45-54

← 1 2 3 4 5 6 7 8 9 10 →