Synthesis of the fully functionalized ABCDE ring moiety of ciguatoxin

被引：29

作者：

Kobayashi, S ^{[1
]}

Alizadeh, BH ^{[1
]}

Sasaki, S ^{[1
]}

Oguri, H ^{[1
]}

Hirama, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1021/ol0364475

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fully functionalized ABCDE ring moiety of ciguatoxin (CTX), the major causative agent of ciguatera poisoning, was synthesized for the first time. The present strategy involves the efficient installation of the C5-dihydroxybutenyl substituent and construction of the tetrahydrooxepin E ring using a novel alpha-chlorosulfide synthon.

引用

页码：751 / 754

页数：4

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