Urine samples before dinner are preferable when studying changes in endogenous nitrate production under uncontrolled dietary conditions

被引:22
作者
Egberts, J
Soederhuizen, W
机构
[1] Dept. of Obstetrics and Gynecology, Leiden University Medical Center, Building 1, P3-P, 2300 RC Leiden
关键词
nitrate; nitrate/creatinine ratio; urine; dietary intake; nitric oxide; men;
D O I
10.1016/0009-8981(96)06380-2
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Changes in nitric oxide production result in changes in nitrate excretion, but these are difficult to detect if the daily intake of nitrate varies substantially. Instead of using a sample of the combined urine produced in 24 h for analysis, we studied the urine nitrate concentration in urine discharge at various times of the day. This was done with urine samples from each of seven men after a high dietary nitrate intake, followed by a low dietary intake 24 h later. The lowest variability in nitrate concentration was found in the samples before dinner (late afternoon) (511 +/- 201 (S.D.) mu mol/l). However, the pre-dinner samples after a day with a nitrate-rich meal had still a 40% increased nitrate concentration (623 +/- 147 mu mol/l), when compared with samples before the high nitrate diet (440 +/- 90 mu mol/l; P < 0.05). This effect disappeared on the second day after the high nitrate meal (476 +/- 108 mu mol/l). Similar results were found when using the nitrate/creatinine ratio. We conclude that urine samples taken before nitrate rich meals are the most reliable samples for estimating (changes in) endogenous nitrate production.
引用
收藏
页码:141 / 148
页数:8
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