A lattice relaxation algorithm for three-dimensional Poisson-Nernst-Planck theory with application to ion transport through the gramicidin A channel

被引：226

作者：

Kurnikova, MG

Coalson, RD ^{[1
]}

Graf, P

Nitzan, A

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[2] Tel Aviv Univ, Dept Chem, IL-69978 Tel Aviv, Israel

来源：

BIOPHYSICAL JOURNAL | 1999年 / 76卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0006-3495(99)77232-2

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A lattice relaxation algorithm is developed to solve the Poisson-Nernst-Planck (PNP) equations for ion transport through arbitrary three-dimensional volumes. Calculations of systems characterized by simple parallel plate and cylindrical pore geometries are presented in order to calibrate the accuracy of the method. A study of ion transport through gramicidin A dimer is carried out within this PNP framework. Good agreement with experimental measurements is obtained. Strengths and weaknesses of the PNP approach are discussed.

引用

页码：642 / 656

页数：15

共 61 条

[21] THE THEORY OF ION-TRANSPORT THROUGH MEMBRANE CHANNELS
COOPER, K
JAKOBSSON, E
WOLYNES, P
[J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1985, 46 (01) : 51 - 96
[22] CRYSTAL-STRUCTURES EXPLAIN FUNCTIONAL-PROPERTIES OF 2 ESCHERICHIA-COLI PORINS
COWAN, SW
SCHIRMER, T
RUMMEL, G
STEIERT, M
GHOSH, R
PAUPTIT, RA
JANSONIUS, JN
ROSENBUSCH, JP
[J]. NATURE, 1992, 358 (6389) : 727 - 733
[23] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity
Doyle, DA
Cabral, JM
Pfuetzner, RA
Kuo, AL
Gulbis, JM
Cohen, SL
Chait, BT
MacKinnon, R
[J]. SCIENCE, 1998, 280 (5360) : 69 - 77
[24] Ionic channels in biological membranes: Natural nanotubes
Eisenberg, B
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (03) : 117 - 123
[25] Computing the field in proteins and channels
Eisenberg, RS
[J]. JOURNAL OF MEMBRANE BIOLOGY, 1996, 150 (01) : 1 - 25
[26] SODIUM IN GRAMICIDIN - AN EXAMPLE OF A PERMION
ELBER, R
CHEN, DP
ROJEWSKA, D
EISENBERG, R
[J]. BIOPHYSICAL JOURNAL, 1995, 68 (03) : 906 - 924
[27] RELAXATIONS, FLUCTUATIONS AND ION TRANSFER ACROSS MEMBRANES
FISHMAN, HM
[J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1985, 46 (02) : 127 - 162
[28] Hille B., 1992, IONIC CHANNELS EXCIT
[29] THE DETERMINATION OF BINDING CONSTANTS OF MICELLAR-PACKAGED GRAMICIDIN-A BY C-13-NMR AND NA-23-NMR
JING, NJ
PRASAD, KU
URRY, DW
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1238 (01): : 1 - 11
[30] REFINED STRUCTURE OF THE PORIN FROM RHODOPSEUDOMONAS-BLASTICA - COMPARISON WITH THE PORIN FROM RHODOBACTER-CAPSULATUS
KREUSCH, A
SCHULZ, GE
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 243 (05) : 891 - 905

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