Hepatic iron overload in thalassemic patients: Proposal and validation of an MRI method of assessment

被引:24
作者
Bonetti, MG
CastriotaScanderbeg, A
Criconia, GM
Mazza, P
Sacco, M
Amurri, B
Masi, C
机构
[1] OSPED UMBERTO I & TORRETTE,SERV RADIOL & DIAGNOST IMMAGINI,ANCONA,ITALY
[2] IRCCS CASA SOLLIEVO SOFFERENZA,DIPARTIMENTO DIAGNOST IMMAGINI,SAN GIOVANNI ROTO,ITALY
[3] IRCCS CASA SOLLIEVO SOFFERENZA,REPARTO CARDIOL,SAN GIOVANNI ROTO,ITALY
[4] OSPED SS ANNUNZIATA,SERV EMATOL,TARANTO,ITALY
[5] IRCCS CASA SOLLIEVO SOFFERENZA,REPARTO PEDIAT,SAN GIOVANNI ROTO,ITALY
关键词
D O I
10.1007/BF01356827
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background. A simple, accurate, reproducible and noninvasive method of body iron overload assessment would be of great clinical use. Objective. The purpose of the study was the implementation of a 0.5-T MRI method for liver iron overload measurement. Materials and methods. Thirty patients with thalassemia major took part in the study. Liver and paraspinal muscle signal intensity (SI) measurements were performed on T1-weighted images and normalized on a standard phantom, and a subjective hemochromatosis grading scale was made on both T1- and T2-weighted images. Serum ferritin levels and tissue iron from liver biopsy specimens were determined for comparison. Results. A close correlation was found between bioptic liver iron and both the liver-to-phantom SI ratio (r = -0.88) and the subjective grading scale (rho = 0.89). Serum ferritin correlated poorly with liver iron deposition, whether assessed by biopsy (r = 0.62) or MRI (r = -0.69). Conclusions. Both the subjective and the quantitative MRI methods proposed here are clinically valuable, with the former being adequate for a gross, the latter for an accurate estimation of tissue iron overload.
引用
收藏
页码:650 / 656
页数:7
相关论文
共 16 条
[1]  
BONKOWSKY HL, 1990, GASTROENTEROLOGY, V55, P1079
[2]   MAGNETIC-RESONANCE IMAGING OF TRANSFUSIONAL HEMOSIDEROSIS COMPLICATING THALASSEMIA MAJOR [J].
BRASCH, RC ;
WESBEY, GE ;
GOODING, CA ;
KOERPER, MA .
RADIOLOGY, 1984, 150 (03) :767-771
[3]   MAGNETIC-SUSCEPTIBILITY MEASUREMENT OF HUMAN IRON STORES [J].
BRITTENHAM, GM ;
FARRELL, DE ;
HARRIS, JW ;
FELDMAN, ES ;
DANISH, EH ;
MUIR, WA ;
TRIPP, JH ;
BELLON, EM .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (27) :1671-1675
[4]  
CHAPMAN RWG, 1980, BRIT MED J, V280, P4429
[5]   HEPATIC IRON OVERLOAD - DIAGNOSIS AND QUANTIFICATION BY NONINVASIVE IMAGING [J].
CHEZMAR, JL ;
NELSON, RC ;
MALKO, JA ;
BERNARDINO, ME .
GASTROINTESTINAL RADIOLOGY, 1990, 15 (01) :27-31
[6]  
FOSBURG MT, 1990, BLOOD, V76, P435
[7]   HEPATIC IRON OVERLOAD - QUANTITATIVE MR IMAGING [J].
GOMORI, JM ;
HOREV, G ;
TAMARY, H ;
ZANDBACK, J ;
KORNREICH, L ;
ZAIZOV, R ;
FREUD, E ;
KRIEF, O ;
BENMEIER, J ;
ROTEM, H ;
KUSPET, M ;
ROSEN, P ;
RACHMILEWITZ, EA ;
LOEWENTHAL, E ;
GORODETSKY, R .
RADIOLOGY, 1991, 179 (02) :367-369
[8]   MR EVALUATION OF LIVER IRON OVERLOAD [J].
HERNANDEZ, RJ ;
SARNAIK, SA ;
LANDE, I ;
AISEN, AM ;
GLAZER, GM ;
CHENEVERT, T ;
MARTEL, W .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1988, 12 (01) :91-94
[9]   NONINVASIVE QUANTITATION OF LIVER IRON-OVERLOAD BY MAGNETIC-RESONANCE-IMAGING [J].
KALTWASSER, JP ;
GOTTSCHALK, R ;
SCHALK, KP ;
HARTL, W .
BRITISH JOURNAL OF HAEMATOLOGY, 1990, 74 (03) :360-363
[10]  
LIFSCHITS DA, 1974, NEW ENGL J MED, V290, P1213