Staphylococcal resistance to antimicrobial peptides of mammalian and bacterial origin

被引：81

作者：

Peschel, A

Collins, LV

机构：

[1] Univ Tubingen, D-72076 Tubingen, Germany

[2] Gothenburg Univ, Dept Rheumatol, S-41346 Gothenburg, Sweden

来源：

PEPTIDES | 2001年 / 22卷 / 10期

关键词：

Staphylococcus aureus; host defense peptides; bacteriocins; innate immunity; animal studies; defensins; protegrins; platelet microbicidal proteins; thrombocidins; lantibiotics; teichoic acids; ABC transporters; secondary transporters; immunomodulation;

D O I：

10.1016/S0196-9781(01)00500-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial host defense peptides, such as defensins, protegrins, and platelet microbicidal proteins are deployed by mammalian skin, epithelia, phagocytes, and platelets in response to Staphylococcus aureus infection. In addition, staphylococcal products with similar structures and activities, called bacteriocins, inhibit competing microorganisms. Staphylococci have developed resistance mechanisms, which are either highly specific for certain host defense peptides or bacteriocins or which broadly protect against a range of cationic antimicrobial peptides. Experimental infection models can be used to study the molecular mechanisms of antimicrobial peptides, the peptide resistance strategies of S. aureus, and the therapeutic potential of peptides in staphylococcal diseases. (C) 2001 Elsevier Science, Inc. All rights reserved.

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页码：1651 / 1659

页数：9

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