Susceptibility to type I diabetes: HLA-DQ and DR revisited

被引：277

作者：

She, JX ^{[1
]}

机构：

[1] UNIV FLORIDA,COLL MED,DEPT PATHOL IMMUNOL & LAB MED,GAINESVILLE,FL 32610

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 07期

关键词：

D O I：

10.1016/0167-5699(96)10014-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ alpha beta trans-complementation.

引用

页码：323 / 329

页数：7

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