The synthesis of Ambrox®-like compounds starting from (+)-larixol.: Part 2

被引：22

作者：

Bolster, MG

Lagnel, BMF

Jansen, BJM

Morin, C

de Groot, A

机构：

[1] Univ Wageningen & Res Ctr, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands

[2] Univ Grenoble 1, CNRS, UMR 5616, Etud Dynam & Struct Select Lab, F-38041 Grenoble, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 39期

关键词：

larixol; Ambrox (R)-like compounds; Delta(6)-Ambroxene;

D O I：

10.1016/S0040-4020(01)00818-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several Ambroxe((R))-like compounds were synthesized in an enantiomerically pure form, and in relatively short procedures, starting from (+)-larixol. Triol 5 and enone 6 are important intermediates in these syntheses. The formation of Delta (6)-Ambrox((R))-type ethers was achieved by a new cyclization approach via ionization of the C(6)-allylic alcohol in ring B. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8369 / 8379

页数：13

共 55 条

[31]

MENDES FNP, 1994, PHYTOCHEMISTRY, V35, P1499, DOI 10.1016/S0031-9422(00)86884-3

[32] Oxidative degradation of larixol and larixyl acetate. [J].