Total synthesis of (+)-pramanicin and stereochemical elucidation of the natural product

被引：28

作者：

Barrett, AGM ^{[1
]}

Head, J

Smith, ML

Stock, NS

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] Celltech Ltd, Therapeut, Slough SL1 4EN, Berks, England

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 02期

关键词：

D O I：

10.1039/a807988i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total synthesis of (+)-pramanicin is achieved through a 'one pot' Michael addition of an aminosilyl zincate species to an alpha,beta-unsaturated lactam and quenching of the resultant enolate with an alpha,beta-unsaturated gamma,delta-epoxy aldehyde.

引用

页码：133 / 134

页数：2

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