Hydroxamate inhibitors of Aeromonas hydrophila AE036 metallo-β-lactamase

被引：45

作者：

Walter, MW

Valladares, MH

Adlington, RM

Amicosante, G

Baldwin, JE

Frère, JM

Galleni, M

Rossolini, GM

Schofield, CJ

机构：

[1] Univ Liege, Ctr Ingn Prot B6, B-4000 Liege, Belgium

[2] Dyson Perrins Lab, Oxford OX1 3QY, England

[3] Univ Aquila, Dipartimento Sci & Tecnol Biomed, I-67100 Laquila, Italy

[4] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy

来源：

BIOORGANIC CHEMISTRY | 1999年 / 27卷 / 01期

关键词：

D O I：

10.1006/bioo.1998.1111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amino acid derived hydroxamates were synthesized and tested for inhibitory activity against different metallo-beta-lactamases. Several compounds inhibited the clinically relevant enzyme from Aeromonas hydrophila AE036. (C) 1999 Academic Press.

引用

页码：35 / 40

页数：6

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