A novel total synthesis of (+)-himbacine, a potent antagonist of the muscarinic receptor of M2 subtype

被引：49

作者：

Takadoi, M ^{[1
]}

Katoh, T ^{[1
]}

Ishiwata, A ^{[1
]}

Terashima, S ^{[1
]}

机构：

[1] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 17期

关键词：

alkaloids; stereocontrol; Diels-Alder reaction; natural products;

D O I：

10.1016/S0040-4039(99)00473-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title total synthesis was achieved by a method featuring highly stereoselective intermolecular Dials-Alder reaction of the tetrahydroisobenzofuran 5 with the chiral butenolide 6 as the key step. The cycloadduct 4 was converted to the title alkaloid by way of the known sulfone 2 in 17 steps. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3399 / 3402

页数：4

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