ALZHEIMERS THERAPY - AN APPROACH TO NOVEL MUSCARINIC LIGANDS BASED UPON THE NATURALLY-OCCURRING ALKALOID HIMBACINE

被引:46
作者
KOZIKOWSKI, AP
FAUQ, AH
MILLER, JH
MCKINNEY, M
机构
[1] Neurochemistry, Mayo Clinic Jacksonville, Jacksonville, FL 32224
[2] Neuropharmacology Research, Mayo Clinic Jacksonville, Jacksonville, FL 32224
关键词
D O I
10.1016/S0960-894X(00)80534-X
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The naturally occurring alkaloid himbacine has been found to be a potent muscarinic antagonist that displays selectivity for M2 or M4 receptors. Using himbacine as a lead compound we have begun to explore its structure-activity profile in order to arrive at an analogue for possible use in cholinergic pharmacotherapy.
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页码:797 / 802
页数:6
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