ALZHEIMERS THERAPY - AN APPROACH TO NOVEL MUSCARINIC LIGANDS BASED UPON THE NATURALLY-OCCURRING ALKALOID HIMBACINE

被引：46

作者：

KOZIKOWSKI, AP

FAUQ, AH

MILLER, JH

MCKINNEY, M

机构：

[1] Neurochemistry, Mayo Clinic Jacksonville, Jacksonville, FL 32224

[2] Neuropharmacology Research, Mayo Clinic Jacksonville, Jacksonville, FL 32224

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80534-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The naturally occurring alkaloid himbacine has been found to be a potent muscarinic antagonist that displays selectivity for M2 or M4 receptors. Using himbacine as a lead compound we have begun to explore its structure-activity profile in order to arrive at an analogue for possible use in cholinergic pharmacotherapy.

引用

页码：797 / 802

页数：6

共 17 条

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