aldol reactions;
copper and compounds;
natural products;
D O I:
10.1016/S0040-4039(98)02130-3
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
An unprecedented tandem conjugate reduction-intramolecular aldol cyclization using Stryker's reagent produced diastereomers of 5 from the ketoester precursor 8. Compound 5c with the trans-fused perhydroazulene carboskeleton as in pseudolaric acid A was formed as a minor isomer, while the all-cis 5b was obtained as the major product. The structures of the two diastereomers have been determined by X-ray crystallography. (C) 1998 Elsevier Science Ltd. All rights reserved.