A conjugate reduction-intramolecular aldol strategy toward the synthesis of pseudolaric acid A

被引：60

作者：

Chiu, P ^{[1
]}

Chen, B ^{[1
]}

Cheng, KF ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

aldol reactions; copper and compounds; natural products;

D O I：

10.1016/S0040-4039(98)02130-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented tandem conjugate reduction-intramolecular aldol cyclization using Stryker's reagent produced diastereomers of 5 from the ketoester precursor 8. Compound 5c with the trans-fused perhydroazulene carboskeleton as in pseudolaric acid A was formed as a minor isomer, while the all-cis 5b was obtained as the major product. The structures of the two diastereomers have been determined by X-ray crystallography. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9229 / 9232

页数：4