Targeting Fas/FasL signaling, a new strategy for maintaining bone health

被引：14

作者：

Imai, Yuuki ^{[1
]}

Kouzmenko, Alexander ^{[2
]}

Kato, Shigeaki ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan

[2] Alfaisal Univ, Coll Sci & Gen Studies, Riyadh, Saudi Arabia

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2011年 / 15卷 / 10期

关键词：

bone disorder; Fas; osteoarthrosis; osteoporosis; rheumatoid arthritis; POSTMENOPAUSAL WOMEN; FAS LIGAND; OSTEOPOROSIS; METHYLTRANSFERASE; RECEPTOR; CANCER; ALPHA; MASS;

D O I：

10.1517/14728222.2011.600690

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The treatment of osteoporosis has been a critical issue in today's medical situation. Various therapeutic agents and strategies have been investigated and applied, and have proven successful in the treatment of osteoporosis. However, some concerns still remain, such as the adverse effects of such treatments. From this point of view, a search for novel therapeutic targets, such as Fas signaling, remains important.

引用

收藏

页码：1143 / 1145

页数：3

相关论文

共 21 条

[1]

Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women [J].

Barrett-Connor, Elizabeth ;

Mosca, Lori ;

Collins, Peter ;

Geiger, Mary Jane ;

Grady, Deborah ;

Kornitzer, Marcel ;

McNabb, Michelle A. ;

Wenger, Nanette K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (02) :125-137

[2]

Effect of Osteoporosis Treatment on Mortality: A Meta-Analysis [J].

Bolland, Mark J. ;

Grey, Andrew B. ;

Gamble, Greg D. ;

Reid, Ian R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (03) :1174-1181

[3]

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis [J].

Cummings, Steven R. ;

San Martin, Javier ;

McClung, Michael R. ;

Siris, Ethel S. ;

Eastell, Richard ;

Reid, Ian R. ;

Delmas, Pierre ;

Zoog, Holly B. ;

Austin, Matt ;

Wang, Andrea ;

Kutilek, Stepan ;

Adami, Silvano ;

Zanchetta, Jose ;

Libanati, Cesar ;

Siddhanti, Suresh ;

Christiansen, Claus .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (08) :756-765

[4]

Bisphosphonates for Osteoporosis [J].

Favus, Murray J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (21) :2027-2035

[5]

RETRACTED: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis (Retracted Article) [J].

Fujiki, Ryoji ;

Chikanishi, Toshihiro ;

Hashiba, Waka ;

Ito, Hiroaki ;

Takada, Ichiro ;

Roeder, Robert G. ;

Kitagawa, Hirochika ;

Kato, Shigeaki .

NATURE, 2009, 459 (7245) :455-U179

[6]

Convergence between bone and energy homeostases: Leptin regulation of bone mass [J].

Karsenty, Gerard .

CELL METABOLISM, 2006, 4 (05) :341-348

[7]

RETRACTED: DNA demethylation in hormone-induced transcriptional derepression (Retracted article. See vol. 486, pg. 280, 2012) [J].

Kim, Mi-Sun ;

Kondo, Takeshi ;

Takada, Ichiro ;

Youn, Min-Young ;

Yamamoto, Yoko ;

Takahashi, Sayuri ;

Matsumoto, Takahiro ;

Fujiyama, Sally ;

Shirode, Yuko ;

Yamaoka, Ikuko ;

Kitagawa, Hirochika ;

Takeyama, Ken-Ichi ;

Shibuya, Hiroshi ;

Ohtake, Fumiaki ;

Kato, Shigeaki .

NATURE, 2009, 461 (7266) :1007-1012

[8]

RETRACTED: The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome (Retracted article. See vol. 149, pg. 245, 2012) [J].

Kitagawa, H ;

Fujiki, R ;

Yoshimura, K ;

Mezaki, Y ;

Uematsu, Y ;

Matsui, D ;

Ogawa, S ;

Unno, K ;

Okubo, M ;

Tokita, A ;

Nakagawa, T ;

Ito, T ;

Ishimi, Y ;

Nagasawa, H ;

Matsumoto, T ;

Yanagisawa, J ;

Kato, S .

CELL, 2003, 113 (07) :905-917

[9]

Targeting Fas in osteoresorptive disorders [J].

Kovacic, Natasa ;

Grcevic, Danka ;

Katavic, Vedran ;

Lukic, Ivan Kresimir ;

Marusic, Ana .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2010, 14 (10) :1121-1134

[10]

Unique ERα Cistromes Control Cell Type-Specific Gene Regulation [J].

Krum, Susan A. ;

Miranda-Carboni, Gustavo A. ;

Lupien, Mathieu ;

Eeckhoute, Jerome ;

Carroll, Jason S. ;

Brown, Myles .

MOLECULAR ENDOCRINOLOGY, 2008, 22 (11) :2393-2406