Drugs, Nutrients, and Phytoactive Principles Improving the Health Span of Rodent Models of Human Age-Related Diseases

被引：11

作者：

Lebel, Michel ^{[1
]}

Picard, Frederic ^{[2
]}

Ferland, Guylaine ^{[3
]}

Gaudreau, Pierrette ^{[4
]}

机构：

[1] Univ Laval, Dept Mol Biol Med Biochem & Pathol, Ctr Rech Cancerol, Hop Hotel Dieu Quebec, Quebec City, PQ G1R 2J6, Canada

[2] Inst Univ Cardiol & Pneumol Quebec, Dept Pharm, Ctr Rech, Quebec City, PQ, Canada

[3] Univ Montreal, Dept Nutr, Inst Univ Geriatrie Montreal Res Ctr, Montreal, PQ H3C 3J7, Canada

[4] Univ Montreal, Dept Med, Lab Neuroendocrinol Aging, Ctr Hosp Univ Montreal Res Ctr, Montreal, PQ H3C 3J7, Canada

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2012年 / 67卷 / 02期

基金：

加拿大健康研究院;

关键词：

Rodents; Aging; Nutrition; Metabolic drugs; Phytoactive principles; GENETICALLY HETEROGENEOUS MICE; EXTENDS LIFE-SPAN; NEURONAL SIGNAL-TRANSDUCTION; SMALL-MOLECULE ACTIVATORS; ACETYL-L-CYSTEINE; E-DEFICIENT MICE; CALORIC RESTRICTION; VITAMIN-E; OXIDATIVE-DAMAGE; MOUSE MODEL;

D O I：

10.1093/gerona/glr038

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Rodents are often the species of choice to examine the effect of drugs on survival and on the progression of specific diseased tissues. This statement is also true for research laboratories working in the field of nutrition and aging. In addition to diets that can reduce the life expectancy of rodents, such as diabetogenic or high-fat diets, genetically modified rodents exhibiting different accelerated age-associated diseases also provide important biologic tools to decipher the impact of drugs, nutrients, or phytoactive compounds on their health and life span. This review covers some of the chemicals believed to decelerate the appearance of age-related diseases in different rodent models. Such chemicals include antioxidants, anti-inflammatory molecules, modulators of metabolic sensors, calorie restriction mimetics, and vegetal polyphenolic compounds that affect mitochondrial functions, cellular proliferation or differentiation as well as cell functionality.

引用

页码：140 / 151

页数：12

共 139 条

[41] Rapamycin fed late in life extends lifespan in genetically heterogeneous mice [J].