Extracellular matrix players in metastatic niches

被引：75

作者：

Oskarsson, Thordur ^{[3
]}

Massague, Joan ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol & Genet Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

[3] Heidelberg Inst Stem Cell Technol & Expt Med HI S, Heidelberg, Germany

来源：

EMBO JOURNAL | 2012年 / 31卷 / 02期

关键词：

BREAST-CANCER CELLS; TENASCIN-C; LUNGS;

D O I：

10.1038/emboj.2011.469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent reports, including one in a current issue of Nature, point at the extracellular matrix (ECM) proteins periostin and tenascin C (TNC) as key metastatic niche molecules. By enhancing Wnt and Notch signalling in cancer cells, these proteins provide physical as well as signalling support for metastasis-initiating cells. These findings underscore the importance of the ECM environment in cancer and provide potential drug targets against metastasis.

引用

页码：254 / 256

页数：3

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