Concise survey of Staphylococcus aureus virulence factors that promote adhesion and damage to peri-implant tissues

被引：40

作者：

Arciola, Carla Renata ^{[1
,2
]}

Visai, Livia ^{[3
,4
,5
]}

Testoni, Francesca ^{[1
]}

Arciola, Susanna ^{[1
,6
]}

Campoccia, Davide ^{[1
]}

Speziale, Pietro ^{[3
]}

Montanaro, Lucio ^{[1
,2
]}

机构：

[1] Rizzoli Orthopaed Inst, Res Unit Implant Infect, I-40136 Bologna, Italy

[2] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[3] Univ Pavia, Dept Biochem, I-27100 Pavia, Italy

[4] Univ Pavia, Ctr Tissue Engn CIT, Salvatore Maugeri Fdn IRCCS, I-27100 Pavia, Italy

[5] Int Ctr Studies & Res Biomed ICB, Luxembourg, Luxembourg

[6] Osped Buon Consiglio Fatebenefratelli, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2011年 / 34卷 / 09期

关键词：

Staphylococcus aureus; MSCRAMMs; Biofilm; Toxins; agr; Implant infection; FIBRONECTIN-BINDING PROTEINS; MOLECULAR EPIDEMIOLOGY; COLLAGEN ADHESIN; INTERCELLULAR-ADHESION; ICA LOCUS; ORTHOPEDIC INFECTIONS; CELLULAR INVASION; BIOFILM FORMATION; SEPTIC ARTHRITIS; SLIME PRODUCTION;

D O I：

10.5301/ijao.5000046

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Staphylococcus aureus is the leading cause of infection in orthopedic implants and of osteomyelitis consequent to it. Here we focus on the wide array of virulence factors that endow S. aureus with its abilities to colonize pen-prosthesis tissues and to attack and damage them. Following an infective strategy orchestrated by agr locus, Staphylococcus aureus first deploys virulence factors for adhesion to the prosthesis and pen-prosthesis tissues and then launches its attack by delivering destructive factors.

引用

页码：771 / 780

页数：10

共 99 条

[21] The presence of both bone sialoprotein-binding protein gene and collagen adhesin gene as a typical virulence trait of the major epidemic cluster in isolates from orthopedic implant infections [J].