DNA base excision repair as a biomarker in molecular epidemiology studies

被引：51

作者：

Collins, Andrew R. ^{[1
]}

Gaivao, Isabel

机构：

[1] Univ Oslo, Dept Nutr, Fac Med, N-0316 Oslo, Norway

[2] Univ Tras Os Montes & Alto Douro, Genet & Biotechnol Dept, P-5001 Vila Real, Portugal

来源：

MOLECULAR ASPECTS OF MEDICINE | 2007年 / 28卷 / 3-4期

关键词：

DNA repair; base excision repair; in vitro assay; biomarker; molecular epidemiology; comet assay;

D O I：

10.1016/j.mam.2007.05.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Base excision repair can be measured in human lymphocytes by a variety of techniques, the most convenient of which are probably in vitro assays of the activity of a cell extract on a DNA substrate containing specific lesions such as 8-oxoguanine. Inter-individual variation in base excision repair ranges from about 3-fold to 10-fold in different studies. Repair has been variously reported to decline or to increase with the age of the individual. Few studies of environmental or occupational exposure and repair have been carried out, but it seems that styrene exposure induces base excision repair activity. In several nutritional intervention trials, with kiwifruit, coenzyme Q(10) and carrots, a significant enhancement of repair has been noted. Activity of 8-oxoguanine DNA glycosylase is significantly affected by the Ser326Cys polymorphism in hOGG1. In cancer case-control studies, low repair activity is consistently associated with occurrence of the disease. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：307 / 322

页数：16

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