CNS effects of heavy particle irradiation in space: Behavioral implications

被引：42

作者：

Joseph, JA ^{[1
]}

Erat, S

Rabin, BM

机构：

[1] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[2] Univ Maryland, Baltimore, MD 21228 USA

来源：

LIFE SCIENCES: SPACE FLIGHT AND THE CENTRAL NERVOUS SYSTEM: THE POTENTIAL INDEPENDENT AND SYNERGISTIC EFFECTS OF MICROGRAVITY AND RADIATION | 1998年 / 22卷 / 02期

关键词：

D O I：

10.1016/S0273-1177(98)80012-4

中图分类号：

V [航空、航天];

学科分类号：

08 ; 0825 ;

摘要：

Research from several sources indicates that young (3 mo) rats exposed to heavy particle irradiation (Fe-56 irradiation) produces changes in motor behavior as well as alterations in neuronal transmission similar to those seen in aged (22-24 mo) rats. These changes are specific to neuronal systems that are affected by aging. Since Fe-56 particles make up approximately 1-2% of cosmic rays, these findings suggest that the neuronal effects of heavy particle irradiation on long-term space flights may be significant, and may even supercede subsequent mutagenic effects in their mission capabilities. It is suggested that among other methods, it may be possible to utilize nutritional modification procedures to offset the putative delterious effects of these particles in space. Published by Elsevier Science Ltd on behalf of COSPAR.

引用

页码：209 / 216

页数：8

共 46 条

[21] Age differences in sensitivity to H2O2- or NO-induced reductions in K+-evoked dopamine release from superfused striatal slices: Reversals by PBN or Trolox [J].

Joseph, JA ;

VillalobosMolina, R ;

Denisova, N ;

Erat, S ;

Cutler, R ;

Strain, J .

FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (06) :821-830

[22] SELECTIVE CROSS-ACTIVATION INHIBITION OF 2ND MESSENGER SYSTEMS AND THE REDUCTION OF AGE-RELATED DEFICITS IN THE MUSCARINIC CONTROL OF DOPAMINE RELEASE FROM PERIFUSED RAT STRIATA [J].

JOSEPH, JA ;

KOWATCH, MA ;

MAKI, T ;

ROTH, GS .

BRAIN RESEARCH, 1990, 537 (1-2) :40-48

[23] AGE-SPECIFIC ALTERATIONS IN MUSCARINIC STIMULATION OF K+-EVOKED DOPAMINE RELEASE FROM STRIATAL SLICES BY CHOLESTEROL AND S-ADENOSYL-L-METHIONINE [J].

JOSEPH, JA ;

VILLALOBOSMOLINA, R ;

YAMAGAMI, K ;

ROTH, GS ;

KELLY, J .

BRAIN RESEARCH, 1995, 673 (02) :185-193

[24]

JOSEPH JA, 1991, CHALLENGES AGING 199, P167

[25] GINKGO-BILOBA [J].

KLEIJNEN, J ;

KNIPSCHILD, P .

LANCET, 1992, 340 (8828) :1136-1139

[26]

KLEIJNEN J, 1992, BRIT J CLIN PHARMACO, V34, P358

[27]

MISSIAEN L, 1991, NATURE, V352, P242

[28]

National Council on Radiation Protection and Measurements, 1989, 98 NCRP

[29] CA2+-INDUCED INCREASE IN OXIDATIVE-METABOLISM OF DISSOCIATED MAMMALIAN BRAIN NEURONS - EFFECT OF EXTRACT OF GINKGO-BILOBA LEAVES [J].

OYAMA, Y ;

HAYASHI, A ;

UEHA, T .

JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 61 (04) :367-370

[30] MYRICETIN AND QUERCETIN, THE FLAVONOID CONSTITUENTS OF GINKGO-BILOBA EXTRACT, GREATLY REDUCE OXIDATIVE-METABOLISM IN BOTH RESTING AND CA2+-LOADED BRAIN NEURONS [J].

OYAMA, Y ;

FUCHS, PA ;

KATAYAMA, N ;

NODA, K .

BRAIN RESEARCH, 1994, 635 (1-2) :125-129

← 1 2 3 4 5 →