Adaptive Characteristics of Innate Immune Responses in Macrophages

被引：26

作者：

Arts, Rob J. W. ^{[1
]}

Netea, Mihai G. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

来源：

MICROBIOLOGY SPECTRUM | 2016年 / 4卷 / 04期

关键词：

MONONUCLEAR PHAGOCYTES; NONSPECIFIC PROTECTION; ACTIVATED MACROPHAGES; TRAINED IMMUNITY; LYMPHOID-CELLS; MEMORY; RECOGNITION; MECHANISMS; RECEPTORS; INFLAMMATION;

D O I：

10.1128/microbiolspec.MCHD-0023-2015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The innate immune system is considered to have no immune memory. However, lately there has been as shift in paradigm. Cells of the innate immune system, and especially monocytes and macrophages, are capable of building a nonspecific memory, resulting in either better or worse responses to secondary stimulations/ infections, as a result of epigenetic changes. This review gives a general overview of the at-the-moment available data.

引用

页数：8

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