The immunogenicity and impact on nasopharyngeal carriage of fewer doses of conjugate pneumococcal vaccine immunization schedule

被引：30

作者：

Ota, Martin O. ^{[1
]}

Akinsola, Adebayo ^{[1
]}

Townend, John ^{[1
]}

Antonio, Martin ^{[1
]}

Enwere, Godwin ^{[1
,2
]}

Nsekpong, David ^{[1
]}

Bojang, Abdoulie ^{[1
]}

Saaka, Mark ^{[1
]}

Burton, R. L. ^{[4
]}

Zaman, Akram ^{[1
]}

Goldblatt, David ^{[3
]}

Adegbola, Richard A. ^{[1
,5
]}

机构：

[1] Med Res Council MRC Labs, Banjul, Gambia

[2] London Sch Hyg & Trop Med, London WC1, England

[3] UCL, Inst Child Hlth, London, England

[4] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[5] Bill & Melinda Gates Fdn, Seattle, WA USA

来源：

VACCINE | 2011年 / 29卷 / 16期

基金：

英国医学研究理事会;

关键词：

Alternative; Pneumococcus; Conjugate; Vaccine; Schedule; Antibodies; Opsonophagocytic assay; POLYSACCHARIDE VACCINE; ANTIBODY-RESPONSES; ACQUIRED-IMMUNITY; STREPTOCOCCUS-PNEUMONIAE; OTITIS-MEDIA; RURAL AREA; CHILDREN; EFFICACY; INFANTS; DISEASE;

D O I：

10.1016/j.vaccine.2011.01.098

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity and impact on carriage of fewer doses of pneumococcal conjugate vaccine (PCV7) followed by booster with pneumococcal polysaccharide vaccine (PPV) were investigated. 684 infants were assigned randomly to one of the three groups that received one (A), two (B) or three (C) doses of PCV7 between 2 and 4 months of age, plus PPV at 10 months. Following primary vaccination protective antibody titers of > 0.35 mu/ml against the PCV7 serotypes combined increased significantly with the number of PCV7 doses, 44% vs. 77% vs. 94% (p < 0.001), and correlated positively with the opsonophagocytic indices, but negatively with nasopharyngeal carriage of pneumococcus. The differences in antibody responses and pneumococcal carriage between the groups diminished following booster with PPV, implying that administration of one or two doses of PCV7, with a booster dose of PPV might lower the cost of protection against IPD in young children in resource poor countries. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2999 / 3007

页数：9

共 37 条

[11] Immunogenicity and boosting after a reduced number of doses of a pneumococcal conjugate vaccine in infants and toddlers [J].