Epigenetic control of replication origins

被引：27

作者：

Zhou, J ^{[1
]}

Chau, C ^{[1
]}

Deng, Z ^{[1
]}

Stedman, W ^{[1
]}

Lieberman, PM ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

CELL CYCLE | 2005年 / 4卷 / 07期

关键词：

ORC; MCM; OriP; SNF2h; chromatin; EBV; KSHV; HDAC;

D O I：

10.4161/cc.4.7.1823

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Efficient duplication of the eukaryotic genome requires the spatial and temporal coordination of numerous replication origins on each chromosome. Epigenetic factors, like chromatin environment, can have profound effects on origin site selection, utilization frequency, and cell cycle firing time. Precisely how chromatin contributes to origin site selection and timing is not completely understood. Recently, we reported on the cell cycle changes in chromatin structure at the plasmid replication origins of Epstein-Barr Virus (EBV) and Kaposi's Sarcoma-Associated Herpes virus (KSHV).(1,2) These studies and others suggest that cell cycle changes in histone modification and nucleosome remodeling regulate prereplication factor assembly and initiation of DNA replication at origins. We discuss how these studies of viral origins may provide important insights into epigenetic control of cellular chromosome origins.

引用

页码：889 / 892

页数：4

共 51 条

[1] Chromatin regulates origin activity in Drosophila follicle cells [J].