Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

被引：2427

作者：

Zhao, Liping ^{[1
,2
,3
,4
]}

Zhang, Feng ^{[1
,2
]}

Ding, Xiaoying ^{[5
]}

Wu, Guojun ^{[1
,2
]}

Lam, Yan Y. ^{[3
,4
]}

Wang, Xuejiao ^{[5
]}

Fu, Huaqing ^{[1
,2
]}

Xue, Xinhe ^{[1
,2
]}

Lu, Chunhua ^{[6
]}

Ma, Jilin ^{[6
]}

Yu, Lihua ^{[6
]}

Xu, Chengmei ^{[6
]}

Ren, Zhongying ^{[6
]}

Xu, Ying ^{[7
]}

Xu, Songmei ^{[7
]}

Shen, Hongli ^{[7
]}

Zhu, Xiuli ^{[7
]}

Shi, Yu ^{[8
]}

Shen, Qingyun ^{[8
]}

Dong, Weiping ^{[5
]}

Liu, Rui ^{[1
,2
]}

Ling, Yunxia ^{[5
]}

Zeng, Yue ^{[9
]}

Wang, Xingpeng ^{[9
]}

Zhang, Qianpeng ^{[1
,2
]}

Wang, Jing ^{[1
,2
]}

Wang, Linghua ^{[1
,2
]}

Wu, Yanqiu ^{[1
,2
]}

Zeng, Benhua ^{[10
]}

Wei, Hong ^{[10
]}

Zhang, Menghui ^{[1
,2
]}

Peng, Yongde ^{[5
]}

Zhang, Chenhong ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Syst Biomed, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

[3] Rutgers State Univ, Dept Biochem & Microbiol, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA

[4] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA

[5] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Endocrinol & Metab, Sch Med, Shanghai 200080, Peoples R China

[6] Sijing Community Hlth Serv Ctr Songjiang Dist, Shanghai 201601, Peoples R China

[7] Sijing Hosp Songjiang Dist, Shanghai 201601, Peoples R China

[8] Qidong Peoples Hosp, Dept Endocrinol & Metab, Nantong 226200, Jiangsu, Peoples R China

[9] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gastroenterol, Sch Med, Shanghai 200080, Peoples R China

[10] Army Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, Chongqing 400038, Peoples R China

来源：

SCIENCE | 2018年 / 359卷 / 6380期

基金：

中国国家自然科学基金;

关键词：

MICROBIOTA COMPOSITION; GLUCOSE; METAGENOME; GHRELIN; OBESITY; INDEX; ACID; PH;

D O I：

10.1126/science.aao5774

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.

引用

页码：1151 / +

页数：6

共 36 条

[1]

[Anonymous], 2014, China J Diabetes Mellitus, V6, P447

[2]

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