The human Mi-2/NuRD complex and gene regulation

被引：381

作者：

Denslow, S. A. ^{[1
]}

Wade, P. A. ^{[1
]}

机构：

[1] NIEHS, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA

来源：

ONCOGENE | 2007年 / 26卷 / 37期

关键词：

histone deacetylase; chromatin; transcriptional repression; chromatin remodeling;

D O I：

10.1038/sj.onc.1210611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mi-2/(nu) under bar cleosome (r) under bar emodeling and (d) under bar eacetylase ( NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modi. cation relate to gene activity.

引用

页码：5433 / 5438

页数：6

共 67 条

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