Chemistry, Pharmacology, and Metabolism of Emerging Drugs of Abuse

被引：50

作者：

Maurer, Hans H. ^{[1
]}

机构：

[1] Univ Saarland, Dept Expt & Clin Toxicol, Inst Expt & Clin Pharmacol & Toxicol, D-66421 Homburg, Saar, Germany

来源：

THERAPEUTIC DRUG MONITORING | 2010年 / 32卷 / 05期

关键词：

drugs of abuse; designer drugs; herbal drugs; pharmacology; metabolism; CHROMATOGRAPHY-MASS-SPECTROMETRY; QUANTITATIVE STRUCTURE-ACTIVITY; HALLUCINOGENIC MESCALINE ANALOGS; HEPATIC CYTOCHROME-P450 ISOZYMES; ISOLATED RAT HEPATOCYTES; DESIGNER DRUG; TOXICOLOGICAL DETECTION; 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE 2C-B; MITRAGYNA-SPECIOSA; MAIN METABOLITES;

D O I：

10.1097/FTD.0b013e3181eea318

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

In recent years, besides the classic designer drugs of the amphetamine type, a series of new drug classes appeared on the illicit drugs market. The chemistry, pharmacology, toxicology, metabolism, and toxicokinetics is discussed of 2,5-dimethoxy amphetamines, 2,5-dimethoxy phenethylamines, beta-keto-amphetamines, phencyclidine derivatives as well as of herbal drugs, ie, Kratom. They have gained popularity and notoriety as rave drugs. The metabolic pathways, the involvement of cytochrome P450 isoenzymes in the main pathways, and their roles in hepatic clearance are also summarized.

引用

页码：544 / 549

页数：6

共 94 条

[1]

Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors [J].

Acuña-Castillo, C ;

Villalobos, C ;

Moya, PR ;

Sáez, P ;

Cassels, BK ;

Huidobro-Toro, J .

BRITISH JOURNAL OF PHARMACOLOGY, 2002, 136 (04) :510-519

[2]

Metabolic interactions with piperazine-based 'party pill' drugs [J].

Antia, Ushtana ;

Tingle, Malcolm D. ;

Russell, Bruce R. .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2009, 61 (07) :877-882

[3]

Austin Helen, 2004, Australas Psychiatry, V12, P406, DOI 10.1111/j.1440-1665.2004.02137.x

[4]

'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs? [J].

Auwaerter, Volker ;

Dresen, Sebastian ;

Weinmann, Wolfgang ;

Mueller, Michael ;

Puetz, Michael ;

Ferreiros, Nerea .

JOURNAL OF MASS SPECTROMETRY, 2009, 44 (05) :832-837

[5]

Opioid receptors and legal highs:: Salvia divinorum and Kratom [J].

Babu, Kavita M. ;

McCurdy, Christopher R. ;

Boyer, Edward W. .

CLINICAL TOXICOLOGY, 2008, 46 (02) :146-152

[6]

Nonfatal and fatal DOB (2,5-dimethoxy-4-bromamphetamine) overdose [J].

Balíková, M .

FORENSIC SCIENCE INTERNATIONAL, 2005, 153 (01) :85-91

[7]

Three-dimensional quantitative structure-activity relationships of hallucinogenic phenylalkanamine and tryptamine derivatives: Studies using comparative molecular field analysis (CoMFA) [J].

Beuerle, G ;

Kovar, KA ;

Schulze-Alexandru, M .

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, 1997, 16 (06) :447-458

[8]

APPLICATIONS OF HIGH-RESOLUTION SELF-ORGANIZING MAPS TO RETROSYNTHETIC AND QSAR ANALYSIS [J].

BIENFAIT, B .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1994, 34 (04) :890-898

[9]

Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior:: interaction between D1 and 5-HT2A receptors [J].

Body, S. ;

Cheung, T. H. C. ;

Bezzina, G. ;

Asgari, K. ;

Fone, K. C. F. ;

Glennon, J. C. ;

Bradshaw, C. M. ;

Szabadi, E. .

PSYCHOPHARMACOLOGY, 2006, 189 (03) :331-343

[10]

SYNTHESIS AND BODY DISTRIBUTION OF SEVERAL I-131 LABELED CENTRALLY ACTING DRUGS [J].

BRAUN, U ;

SHULGIN, AT ;

BRAUN, G ;

SARGENT, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (12) :1543-1546

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