TRP channels in kidney disease

被引:54
作者
Hsu, Yu-Juei
Hoenderop, Joost G. J.
Bindels, Rene J. M.
机构
[1] Univ Nijmegen St Radboud Hosp, Med Ctr, Dept Physiol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
[2] Tri Serv Gen Hosp, Dept Internal Med, Div Nephrol, Taipei, Taiwan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2007年 / 1772卷 / 08期
关键词
transient receptor potential channel; calcium; magnesium; ion transport; reabsorption;
D O I
10.1016/j.bbadis.2007.02.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mammalian TRP channel proteins form six-transmembrane cation-permeable channels that may be grouped into six subfamilies on the basis of amino acid sequence homology (TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML). Recent studies of TRP channels indicate that they are involved in numerous fundamental cell functions and are considered to play an important role in the pathophysiology of many diseases. Many TRPs are expressed in kidney along different parts of the nephron and growing evidence suggest that these channels are involved in hereditary, as well as acquired kidney disorders. TRPC6, TRPM6, and TRPP2 have been implicated in hereditary focal segmental glomerulosclerosis (FSGS), hypomagnesemia with secondary hypocalcemia (HSH), and polycystic kidney disease (PKD), respectively. In addition, the highly Ca +-selective channel, TRPV5, contributes to several acquired mineral (dys)regulation, such as diabetes mellitus (I)M), acid-base disorders, diuretics, immunosuppressant agents, and vitamin D analogues-associated Ca (2+) imbalance whereas TRPV4 may function as an osmoreceptor in kidney and participate in the regulation of sodium and water balance. This review presents an overview of the current knowledge concerning the distribution of TRP channels in kidney and their possible roles in renal physiology and kidney diseases. (c) 2007 Elsevier B.V All rights. reserved.
引用
收藏
页码:928 / 936
页数:9
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