Reintroduction of the 2G12 epitope in an HIV-1 clade C gp120

被引：19

作者：

Chen, HY ^{[1
]}

Xu, XD ^{[1
]}

Bishop, A ^{[1
]}

Jones, IM ^{[1
]}

机构：

[1] Univ Reading, Sch Anim & Microbial Sci, Reading RG6 6AJ, Berks, England

来源：

AIDS | 2005年 / 19卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1097/01.aids.0000168980.74713.9e

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many clade C isolates of HIV-1 do not react with monoclonal antibody (MAb) 2G12, a broad-ranging human neutralizing MAb that recognizes high mannose carbohydrate groups attached to glycoprotein gp120. We reintroduced a partial and complete 2G12 epitope into a clade C background, HIV-1(CN54), and examined the antibody reactivity of the resulting recombinant molecules. Two glycosylation sites recovered 2G12 binding completely, but some binding was evident after the reintroduction of a single glycosylation site at Asn295.

引用

页码：833 / 835

页数：3

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